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	Provedor de dados BJMBR (2) Autor Perussi,J.R. (2) Barbosa Junior,F. (1) Rodrigues,M. (1) Tita,S.P.S (1) Palavra-chave Cisplatin (1) Cytotoxicity (1) Dipyridamole (1) IC50 (1) Mouse fibroblast lines A31 and B61 (1) Photodynamic therapy (1) Synergism (1) Tumor cells (1) Visible light (1) Water-soluble porphyrins (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2004 (1) 2001 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Dipyridamole increases the cytotoxicity of cisplatin in human larynx cancer cells in vitro BJMBR Rodrigues,M.; Barbosa Junior,F.; Perussi,J.R.. This paper describes the effect of dipyridamole (DIP) on the cytotoxicity of cisplatin in HEp-2 human larynx cancer cells in vitro and the nature of the interaction between cisplatin and dipyridamole. Cytotoxic assays were performed to obtain the IC50 for cisplatin. The cells were treated with 0, 20, 40, 80, 120 or 200 µM cisplatin, with or without a single concentration of DIP and incubated for 60 min at 37ºC and 5% CO2 for 3 days and then counted with a hemocytometer. The accumulation of cisplatin in the cells was measured by atomic absorption and fluorescence was used to determine the membrane binding constant of DIP. In the presence of 10, 20 and 30 µM DIP, the IC50 of cisplatin was reduced by 25, 60 and 82% in HEp-2 cells. Combination index analysis... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cisplatin; Dipyridamole; Synergism; Tumor cells; Cytotoxicity; IC50. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000400017 The effect of porphyrins on normal and transformed mouse cell lines in the presence of visible light BJMBR Tita,S.P.S; Perussi,J.R.. Photodynamic therapy consists of the uptake of a photosensitizing dye, often a porphyrin, by tumor tissue and subsequent irradiation of the tumor with visible light of an appropriate wavelength matched to the absorption spectrum of the photosensitizing dye. This class of molecules produces reactive oxygen species when activated by light, resulting in a direct or indirect cytotoxic effect on the target cells. Photodynamic therapy has been used in the treatment of cancer but the technology has a potential for the treatment of several disease conditions mainly because of its selectivity. However, it is not clear why the porphyrins are retained preferentially by abnormal tissue. This paper describes a study of the effect of the association of porphyrin and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Water-soluble porphyrins; Mouse fibroblast lines A31 and B61; Photodynamic therapy; Visible light. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001001000014 Registros recuperados: 2 Primeira ... 1 ... Última

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